Experiencing multiple miscarriages is emotionally devastating. At Mother Hospitals, Dr. E. Prashanthi Reddy conducts a comprehensive investigation to identify the cause — and designs a personalised treatment plan to give you the best chance of a successful ongoing pregnancy.
MBBS, DGO, PG Diploma in ART – Kiel University, Germany | Recurrent Pregnancy Loss Specialist | TGMC Reg: 50624
Karyotype of both partners identifies balanced chromosomal translocations — a parent can carry a rearrangement that is harmless to them but causes recurrent chromosomally abnormal embryos. PGT-A in IVF selects only normal embryos for transfer.
Antiphospholipid syndrome (APS) causes abnormal blood clotting in the placenta, leading to miscarriage. Tests: lupus anticoagulant, anticardiolipin antibodies, anti-β2GP1. Factor V Leiden, prothrombin mutation screening. Treated with low-dose aspirin + heparin in pregnancy.
Uterine septum, submucosal fibroids, and intrauterine adhesions (Asherman's syndrome) can all cause recurrent miscarriage. Diagnosed by 3D ultrasound or hysteroscopy. Septum resection and adhesion surgery significantly improve outcomes.
Thyroid disorders (hypothyroidism, Hashimoto's) are a common and easily treatable cause of recurrent miscarriage. Prolactin, insulin resistance, and HbA1c are also evaluated. Thyroid TSH should be below 2.5 mIU/L in early pregnancy.
Elevated uterine Natural Killer (NK) cells, elevated CD56+ cells, and activated immune responses can cause implantation failure and early pregnancy loss. Tested via endometrial biopsy or peripheral blood. Treated with steroids, intralipid, or immunoglobulins where indicated.
When miscarriage occurs, testing the products of conception identifies whether loss was chromosomally caused (60% of cases) — guiding whether PGT-A in the next IVF cycle is appropriate.
Thyroid correction, thrombophilia treatment (aspirin + heparin), uterine surgery (septum resection, fibroid removal, adhesion lysis), prolactin control — all before attempting the next pregnancy.
When chromosomal factors are suspected (advanced age, balanced translocation carrier, chromosomally abnormal POC testing), IVF with PGT-A ensures only euploid (chromosomally normal) embryos are transferred — dramatically reducing miscarriage risk.
ERA (Endometrial Receptivity Analysis) identifies the personalised implantation window — critical for recurrent implantation failure cases where the timing of transfer may be off.
High-dose progesterone, low-dose aspirin, and heparin (when indicated) throughout the first trimester to support implantation and early placental development in high-risk cases.
Frequent early scans from 5–6 weeks, serial beta hCG measurements, and dedicated early pregnancy support clinic — providing both medical monitoring and emotional support through the most anxious period.
Formal RPL investigation is recommended after 2 consecutive losses. For women over 35, investigation after even one loss is reasonable given the impact of age on egg quality and chromosomal risk. Early investigation prevents unnecessary delays in finding and treating the cause.
Not at all. Even without any treatment, approximately 60–65% of women with unexplained recurrent miscarriage will have a successful next pregnancy. With investigation and targeted treatment, success rates are significantly higher. PGT-A in particular gives >90% live birth rates when normal embryos are available for transfer.
The ₹99,000 IVF package is the base cost. PGT-A genetic testing is an add-on, quoted separately based on number of embryos biopsied. It is only recommended when clinically indicated (recurrent miscarriage with suspected chromosomal cause, advanced maternal age, prior chromosomally abnormal pregnancy, or balanced translocation carrier).
Yes. Recurrent miscarriage is one of the most emotionally difficult experiences a couple can face. Dr. Prashanthi Reddy and the Mother Hospitals team provide compassionate, non-judgmental care at every visit. Counselling referral is available for couples who need additional emotional support during their journey.